Not Always a Bite

Bat rabies virus can also be found on surface cells like skin (known as epithelial cells), not just in saliva or brain tissue. Because of this, any human contact with a bat, even very minor wounds like superficial scratches, can cause rabies.3,4

Bats Cause 70% of Human Rabies Infections in the US2

Three people in the US contracted rabies in 5 weeks in 2021—all were exposed to the virus by bats. One of the individuals handled the bat with their bare hands.2

ACIP Recommendations Regarding Bats

“Any direct contact between a human and a bat should be evaluated for an exposure. If the person can be reasonably certain a bite, scratch, or mucous membrane exposure did not occur, or if the bat is available for testing and is negative for presence of rabies virus, postexposure prophylaxis is not necessary. Other situations that might qualify as exposures include finding a bat in the same room as a person who might be unaware that a bite or direct contact had occurred (e.g., a deeply sleeping person awakens to find a bat in the room, or an adult witnesses a bat in the room with a previously unattended child, mentally disabled person, or intoxicated person).”1

Learn How to Keep Your Pet Safe From Rabies

Seek Immediate Medical Help if You Suspect You’ve Had Any Direct Contact With a Bat

Important Safety Information for HyperRAB® (rabies immune globulin [human])

Indication and Usage
HYPERRAB® (rabies immune globulin [human]) is indicated for postexposure prophylaxis, along with rabies vaccine, for all persons suspected of exposure to rabies.

Limitations of Use
Persons who have been previously immunized with rabies vaccine and have a confirmed adequate rabies antibody titer should receive only vaccine. For unvaccinated persons, the combination of HYPERRAB and vaccine is recommended for both bite and nonbite exposures regardless of the time interval between exposure and initiation of postexposure prophylaxis. Beyond 7 days (after the first vaccine dose), HYPERRAB is not indicated since an antibody response to vaccine is presumed to have occurred.

Important Safety Information

For infiltration and intramuscular use only.

Severe hypersensitivity reactions may occur with HYPERRAB. Patients with a history of prior systemic allergic reactions to human immunoglobulin preparations are at a greater risk of developing severe hypersensitivity and anaphylactic reactions. Have epinephrine available for treatment of acute allergic symptoms, should they occur.

HYPERRAB is made from human blood and may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

The most common adverse reactions in >5% of subjects during clinical trials were injection-site pain, headache, injection-site nodule, abdominal pain, diarrhea, flatulence, nasal congestion, and oropharyngeal pain.

Do not administer repeated doses of HYPERRAB once vaccine treatment has been initiated as this could prevent the full expression of active immunity expected from the rabies vaccine.

Other antibodies in the HYPERRAB preparation may interfere with the response to live vaccines such as measles, mumps, polio, or rubella. Defer immunization with live vaccines for 4 months after HYPERRAB administration.

Please see full Prescribing Information for HYPERRAB.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088


  1. Manning SE, Rupprecht CE, Fishbein D, et al. Human rabies prevention—United States, 2008: recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep. 2008;57(RR-3):1-28.
  2. CDC reports increase in human rabies cases linked to bats in the U.S. Centers for Disease Control and Prevention (CDC). Accessed January 24, 2022.
  3. Crowcroft NS, Thampi N. The prevention and management of rabies. BMJ. 2015;350:g7827.
  4. Ehnert K, Ponce M, Beeler E. Rabies: which patients need post-exposure prophylaxis? Rx for Prevention (LA County Department of Public Health). November-December 2013.