Here Is a Convenient List of Words Related to Rabies


An inflammation (swelling) of brain tissue caused by an infection or an autoimmune response.


Bodily tissues made up of sheets of similar cells bound closely together. This includes the epidermis (skin); the surfaces of the eyes; and digestive, respiratory, reproductive, and urinary tracts.

Rabies exposure

Any bite, scratch, or wound that allows the saliva or nervous tissue from a potentially rabid animal to get under the skin or come in contact with the eye, nose, or mouth.

HyperRAB®(rabies immune globulin [human])

A high-potency human rabies immune globulin (HRIG) made by Grifols to provide rapid immune protection against rabies in persons who have never been vaccinated against rabies virus.

Human rabies immune globulin (HRIG)

A medication that provides antibodies for immediate use until the body can respond to the vaccine and actively produce antibodies of its own.

HyperTET®(tetanus immune globulin [human])

A tetanus immune globulin (TIG) made by Grifols for immune coverage against tetanus for persons with serious wounds and who also require tetanus vaccine. 


The production of excess saliva.


The complete or partial loss of the ability to move.

Postexposure prophylaxis

Any preventive medical treatment or measure started immediately after exposure to a pathogen, such as rabies, to prevent infection.


An acute, contagious, and fatal viral disease of the nervous system that spreads between mammals.


A fluid secreted by the salivary glands in the mouth, commonly referred to as spit.


A substance used to initiate or increase the production of antibodies to provide immunity against one or more diseases.


Infectious agents usually composed of extremely complex molecules too small to be seen under a microscope. Viruses are capable of growth in living cells and cause various diseases in humans, animals, and plants.

Zoonotic disease

An infectious disease that can be transmitted between species, often from a non-human animal to a human.

Important Safety Information for HyperRAB® (rabies immune globulin [human])

Indication and Usage
HYPERRAB® (rabies immune globulin [human]) is indicated for postexposure prophylaxis, along with rabies vaccine, for all persons suspected of exposure to rabies.

Limitations of Use
Persons who have been previously immunized with rabies vaccine and have a confirmed adequate rabies antibody titer should receive only vaccine. For unvaccinated persons, the combination of HYPERRAB and vaccine is recommended for both bite and nonbite exposures regardless of the time interval between exposure and initiation of postexposure prophylaxis. Beyond 7 days (after the first vaccine dose), HYPERRAB is not indicated since an antibody response to vaccine is presumed to have occurred.

Important Safety Information

For infiltration and intramuscular use only.

Severe hypersensitivity reactions may occur with HYPERRAB. Patients with a history of prior systemic allergic reactions to human immunoglobulin preparations are at a greater risk of developing severe hypersensitivity and anaphylactic reactions. Have epinephrine available for treatment of acute allergic symptoms, should they occur.

HYPERRAB is made from human blood and may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

The most common adverse reactions in >5% of subjects during clinical trials were injection-site pain, headache, injection-site nodule, abdominal pain, diarrhea, flatulence, nasal congestion, and oropharyngeal pain.

Do not administer repeated doses of HYPERRAB once vaccine treatment has been initiated as this could prevent the full expression of active immunity expected from the rabies vaccine.

Other antibodies in the HYPERRAB preparation may interfere with the response to live vaccines such as measles, mumps, polio, or rubella. Defer immunization with live vaccines for 4 months after HYPERRAB administration.

Please see full Prescribing Information for HYPERRAB.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088

Important Safety Information for HyperTET® (tetanus immune globulin [human])

HyperTET® (tetanus immune globulin [human]) is indicated for prophylaxis against tetanus following injury in patients whose immunization is incomplete or uncertain.

HyperTET should be given with caution to patients with a history of prior systemic allergic reactions following the administration of human immunoglobulin preparations.

In patients who have severe thrombocytopenia or any coagulation disorder that would contraindicate intramuscular injections, HyperTET should be given only if the expected benefits outweigh the risks.

Slight soreness at the site of injection and slight temperature elevation may be noted at times. Sensitization to repeated injections of human immunoglobulin is extremely rare. In the course of routine injections of large numbers of persons with immunoglobulin, there have been a few isolated occurrences of angioneurotic edema, nephrotic syndrome, and anaphylactic shock after injection. Administration of live virus vaccines (eg, MMR) should be deferred for approximately 3 months after tetanus immune globulin (human) administration.

HyperTET is made from human plasma. Products made from human plasma may contain infectious agents, such as viruses and theoretically, the Creutzfeldt-Jakob disease (CJD) agent that can cause disease. There is also the possibility that unknown infectious agents may be present in such products.

Please see HyperTET full Prescribing Information for complete prescribing details.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.