keep_pets_safe

How to Keep Your Pets Safe

Vaccination and animal control programs have helped to prevent rabies in most pets. It's important to keep your pets up-to-date on rabies vaccinations. Cats and dogs that spend time outdoors may have more risk of coming into contact with a rabid wild animal, but it is important to also vaccinate indoor pets as well. In the United States, there have been more cases of rabies in cats than in dogs in recent years. Therefore, rabies vaccination is especially important for cats. See your veterinarian for more information on rabies vaccination or take your pets to state/municipal-sponsored rabies clinics.1,2

Animals to Watch Out for Where You Live

Only mammals, including people, can get rabies. Rabies occurs most often in wildlife, particularly raccoons, bats, skunks, and foxes. Wild animals account for an estimated 92% of rabies cases in the United States.1

Learn more about what animals to watch out for in your area.

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Myth or Fact?

Rabies, left untreated, is fatal.

Myth Fact

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Important Safety Information for HyperRAB® (rabies immune globulin [human])

Indication and Usage

HYPERRAB® (rabies immune globulin [human]) is indicated for postexposure prophylaxis, along with rabies vaccine, for all persons suspected of exposure to rabies.

Limitations of Use 

Persons who have been previously immunized with rabies vaccine and have a confirmed adequate rabies antibody titer should receive only vaccine.

For unvaccinated persons, the combination of HYPERRAB and vaccine is recommended for both bite and nonbite exposures regardless of the time interval between exposure and initiation of postexposure prophylaxis.

Beyond 7 days (after the first vaccine dose), HYPERRAB is not indicated since an antibody response to vaccine is presumed to have occurred.

Important Safety Information

For infiltration and intramuscular use only.

Severe hypersensitivity reactions may occur with HYPERRAB. Patients with a history of prior systemic allergic reactions to human immunoglobulin preparations are at a greater risk of developing severe hypersensitivity and anaphylactic reactions. Have epinephrine available for treatment of acute allergic symptoms, should they occur.

HYPERRAB is made from human blood and may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

The most common adverse reactions in >5% of subjects during clinical trials were injection-site pain, headache, injection-site nodule, abdominal pain, diarrhea, flatulence, nasal congestion, and oropharyngeal pain.

Do not administer repeated doses of HYPERRAB once vaccine treatment has been initiated as this could prevent the full expression of active immunity expected from the rabies vaccine.

Other antibodies in the HYPERRAB preparation may interfere with the response to live vaccines such as measles, mumps, polio, or rubella. Defer immunization with live vaccines for 4 months after HYPERRAB administration.  

Please see full Prescribing Information for HyperRAB.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Important Safety Information for HyperTET® (tetanus immune globulin [human])

HyperTET® (tetanus immune globulin [human]) is indicated for prophylaxis against tetanus following injury in patients whose immunization is incomplete or uncertain.

HyperTET should be given with caution to patients with a history of prior systemic allergic reactions following the administration of human immunoglobulin preparations.

In patients who have severe thrombocytopenia or any coagulation disorder that would contraindicate intramuscular injections, HyperTET should be given only if the expected benefits outweigh the risks.

Slight soreness at the site of injection and slight temperature elevation may be noted at times. Sensitization to repeated injections of human immunoglobulin is extremely rare. In the course of routine injections of large numbers of persons with immunoglobulin, there have been a few isolated occurrences of angioneurotic edema, nephrotic syndrome, and anaphylactic shock after injection. Administration of live virus vaccines (eg, MMR) should be deferred for approximately 3 months after tetanus immune globulin (human) administration.

HyperTET is made from human plasma. Products made from human plasma may contain infectious agents, such as viruses and theoretically, the Creutzfeldt-Jakob disease (CJD) agent that can cause disease. There is also the possibility that unknown infectious agents may be present in such products.

Please see HyperTET full Prescribing Information for complete prescribing details.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.


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References:

  1. Ma X, Monroe BP, Wallace RM, et al. Rabies surveillance in the United States during 2019. JAVMA. 2021;258(11):1205-1220.
  2. Rabies facts & prevention tips. American Humane. Updated August 25, 2016. Accessed October 5, 2021. https://www.americanhumane.org/fact-sheet/rabies-facts-prevention-tips/.
  3. How is rabies transmitted? Centers for Disease Control and Prevention (CDC). Centers for Disease Control (CDC). Updated June 11, 2019. Accessed October 1, 2021. https://www.cdc.gov/rabies/transmission/index.html.

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Myth/Fact References:

  1. How is rabies transmitted? Centers for Disease Control and Prevention (CDC). Updated June 11, 2019. Accessed October 1, 2021. https://www.cdc.gov/rabies/transmission/index.html.
  2. Ma X, Monroe BP, Wallace RM, et al. Rabies surveillance in the United States during 2019. JAVMA. 2021;258(11):1205-1220.
  3. What are the signs and symptoms of rabies? Centers for Disease Control and Prevention (CDC). Updated June 11, 2019. Accessed October 1, 2021. https://www.cdc.gov/rabies/symptoms/index.html.